410 products were found matching "K01389"!

Description: Neprilysin/CD10 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 Cells. The accession number is P08473.

CD10 is a 100 kD neutral endopeptidase and a member of the metalloprotease family. It is a type II transmembrane protein also known as common acute lymphoblastic leukemia antigen (CALLA), enkephalinase, and neprilysin. CD10 is expressed on B cell precursors, T cell precursors, and neutrophils. CD10 is involved in B...

Protein function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9....

AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in...

LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM). It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 µM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-beta-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM,...

Thiorphan is an inhibitor of neprilysin (NEP, IC50 = 0.007 µM). It selectivity inhibits NEP over NEP2 (IC50 = 22 µM), as well as angiotensin-converting enzyme (ACE) and endothelin-converting enzyme 1 (ECE1, Kis = >0.1 and >10 µM, respectively, in cell-free assays). Thiorphan (10 µM) increases bradykinin-induced...

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Cay-14178) and AHU377 (Cay-21473), a prodrug of LBQ657 (Cay-19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg/kg)...

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 µM). Phosphoramidon has little or no...

Omapatrilat is an orally bioavailable angiotensin-converting enzyme (ACE) and neprilysin (NEP) inhibitior (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes). It inhibits the pressor response induced by angiotensin I (Cay-24737) in normotensive rats (ED50 = 0.07 µmol/kg) and lowers mean arterial pressure...

Protein function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave...

Description: Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin...

Protein function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9....