Anti-Cathepsin D (CatD, CLN10, CPSD, CTSD, MGC2311)

Anti-Cathepsin D (CatD, CLN10, CPSD, CTSD, MGC2311)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2097-28A.100 100 µg - -

3 - 19 business days*

494.00€
 
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl... more
Product information "Anti-Cathepsin D (CatD, CLN10, CPSD, CTSD, MGC2311)"
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52kD pro enzyme. Activation involves the proteolytic removal of the 43aa profragment and an internal cleavage to generate the two-chain form made up of 34 and 14kD subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52kD precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease. Application: Suitable for use in Western Blot, Immunoprecipitation, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Immunohistochemistry (paraffin): 1-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-CTSD, Anti-CPSD, EC=3.4.23.5
Supplier: United States Biological
Supplier-Nr: C2097-28A

Properties

Application: IHC, IP, WB
Antibody Type: Monoclonal
Clone: 10K133
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human liver cathepsin D.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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