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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C2087-42H.100 | 100 µg | - | - |
3 - 19 business days* |
606.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation... more
Product information "Anti-CASP8 (Caspase-8, CASP-8, ICE-like Apoptotic Protease 5, MORT1-associated CED-3 Homolog, MACH,"
CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-MCH5, EC=3.4.22.61, Anti-Caspase-8 subunit p10, Anti-Caspase-8 subunit p18, Anti-Apoptotic protease Mch-5, Anti-Apoptotic cysteine protease, Anti-ICE-like apoptotic protease 5, Anti-MORT1-associated ced-3 homolog |
Supplier: | United States Biological |
Supplier-Nr: | C2087-42H |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide corresponding to middle region from human Caspase-8(P18). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04398 | Matching products |
UniProt ID : | Q14790 | Matching products |
Gene ID | GeneID 841 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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