Anti-c-Myc, clone EAC-13

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ4861 100 µl - -

3 - 10 business days*

755.00€
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. c-Myc is an oncogene... more
Product information "Anti-c-Myc, clone EAC-13"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. c-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. It elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. Protein function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). [The UniProt Consortium]
Keywords: Anti-MYC, Anti-BHLHE39, Anti-bHLHe39, Anti-Proto-oncogene c-Myc, Anti-Transcription factor p64, Anti-Myc proto-oncogene protein, Anti-Class E basic helix-loop-helix protein 39, c-Myc Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: RQ4861

Properties

Application: IHC (paraffin), WB
Antibody Type: Monoclonal
Clone: EAC-13
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide specific to human c-Myc
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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