Anti-c-erbB2, clone SP3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
900-C01-B37 100 µl - -

3 - 9 business days*

506.00€
 
Protein function: Protein tyrosine kinase that is part of several cell surface receptor... more
Product information "Anti-c-erbB2, clone SP3"
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium]
Keywords: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2
Supplier: Rockland Immunochemicals
Supplier-Nr: 900-C01-B37

Properties

Application: ELISA, IHC, WB
Antibody Type: Monoclonal
Clone: SP3
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: recombinant protein corresponding to amino acid residues encoding the extracellular domain of human c-erbB2 protein
Format: Tissue Culture Supernatant

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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