613 products were found matching "K05083"!

Description: HER2/ERBB2 Domain 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 Cells. The accession number is P04626.

Description: HER2/ERBB2 Protein, Human, Recombinant (His), AF488-Labeled is expressed in HEK293 Cells. The accession number is P04626.

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-ErbB2 (Tyr1221/Tyr1222) antibody detects ErbB2, encoded by the ERBB2 gene, when phosphorylated at tyrosines 1221 and 1222. ErbB2 is also commonly called HER2, NEU, proto oncogene Neu, and...

Zongertinib is an inhibitor of mutant HER2 containing an activating exon 20 insertion (HER2YVMA. IC50 = 13 nM in a cellular phosphorylation assay using HEK cells). It is selective for the inhibition of HER2YVMA over wild-type EGFR (IC50 = 576 nM in a cellular phosphorylation assay using HEK cells). It is also...

Trastuzumab is a humanized IgG1 recombinantmonoclonal antibody that selectively binds to HER2 (eceptor tyrosine-protein kinase ErbB-2) with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast and gastric cancer. Trastuzumab consists of two antigen-specific sites that bind to...

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,...

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,...

Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor....

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with...

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with...

Lapatinib is a dual inhibitor of the EGF receptor (EGFR) and ErbB2 (IC50s = 19 and 3 nM, respectively). It inhibits the growth of EGFR-overexpressing A431 skin cancer and ErbB2-overexpressing SK-BR-3 breast cancer cells (IC50s = 0.14 and 0.124 µM, respectively). Lapatinib also inhibits the growth of ErbB2-amplified...

Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...