Anti-Bub3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-AA0	100 µg		-	-	3 - 8 business days*		848.00€

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Anti-Bub3 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-Bub3"

Anti-Bub3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Bub3 from other sources has not been determined. Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. [The UniProt Consortium]

Keywords:	Anti-BUB3, Anti-Mitotic checkpoint protein BUB3
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-AA0

Properties

Application:	ELISA, IFM, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	16 amino acid synthetic peptide from near the C-terminus of human bub3.
Format:	Purified