Anti-Bub3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40562.50	50 µg		-	-	10 - 15 business days*		551.00€

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Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting... more

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Product information "Anti-Bub3"

Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. [The UniProt Consortium]

Keywords:	Anti-BUB3, Anti-Mitotic checkpoint protein BUB3
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40562

Properties

Application:	ICC, IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, rat (Expected: mouse, hamster)
Immunogen:	Synthetic peptide corresponding to aa. 76-90 of Human Bub3. (DHQLKMHDLNTDQEN)
MW:	37 kD
Format:	Antigen Affinity Purified