Anti-BRCA2

Anti-BRCA2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-434A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-434A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-434A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Involved in double-strand break repair and/or homologous recombination. Binds... more
Product information "Anti-BRCA2"
Protein function: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop- associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). [The UniProt Consortium]
Keywords: Anti-FACD, Anti-BRCA2, Anti-Fanconi anemia group D1 protein, Anti-Breast cancer type 2 susceptibility protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-434A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-434A-T maps to a region between residue 450 and 500 of human Breast Cancer 2, Early Onset using the numbering given in entry NP_000050.1 (GeneID 675).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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