Anti-Beta-catenin

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-012A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-012A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-012A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence... more
Product information "Anti-Beta-catenin"
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. [The UniProt Consortium]
Keywords: Anti-CTNNB, Anti-CTNNB1, Anti-Beta-catenin, Anti-Catenin beta-1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-012A

Properties

Application: WB, IP, IHC, ChIP-Seq
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, X. Laevis, Bovine, Dog)
Immunogen: synthetic peptide. The epitope recognized by A302-012A-T maps to a region between residue 760 and 781 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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