Anti-Bcl-X (Apoptosis Marker), clone SPM165

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Centrosome, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Cytosol, Microtubule organizing center, Mitochondrion inner membrane, Mitochondrion matrix, Mitochondrion outer membrane, Nucleus membrane, Secretory vesicle, Synaptic vesicle membrane. Positive Control: HL-60 or HeLa cells. Reed-Sternberg cells in Hodgkin's lymphoma., Jurkat, K562. Chromosome Location: 20q11.21. Protein Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis , Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) , Isoform Bcl-X(S) promotes apoptosis [The Uniprot Consortium]