- Search results for K04570
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117 products were found matching "K04570"!
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Item number: ELK-ELK7209.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Bcl2L. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Bcl2L. Next,...
Keywords: | Bcl2l, Bcl2l1, Bcl2-L-1, Bcl-2-like protein 1, Apoptosis regulator Bcl-X |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: ELK-EA258.100
Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions. Protein function: Potent inhibitor of cell death. Inhibits...
Keywords: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, Bcl-Xl Rabbit pAb |
Application: | IHC |
Host: | Rabbit |
Species reactivity: | human |
283.00€
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Item number: Cay27369-1
A-1155463 is an inhibitor of Bcl-xL (Ki = is = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected...
Keywords: | 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluoro... |
Application: | Bcl-xL inhibitor |
CAS | 1235034-55-5 |
MW: | 669.8 D |
From 45.00€
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Item number: Cay37311-1
DT2216 is a proteolysis-targeting chimera (PROTAC) composed of the Bcl-2 family inhibitor ABT-263 (Cay-11500) conjugated to a von Hippel-Lindau (VHL) E3 ligase ligand. It selectively induces degradation of Bcl-xL in MOLT-4 T cell acute lymphoblastic leukemia (T-ALL) cells with a 50% degradation concentration (DC50)...
Keywords: | (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperaz... |
Application: | Bcl-xL degradation driving PROTAC |
CAS | 2365172-42-3 |
MW: | 1542.4 D |
From 35.00€
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Item number: Cay14482-100
Gossypol is a racemic mixture of natural polyphenols isolated from parts of the cotton plant (genus Gossypium). It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations....
Keywords: | BL 193, NSC 56817, NSC 624336, Pogosin,... |
Application: | Bcl2 / Bcl-xL inhibitor |
CAS | 303-45-7 |
MW: | 518.6 D |
From 100.00€
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Item number: Cay21478-1
WEHI-539 is an inhibitor of Bcl-xL (IC50 = 1.1 nM) that demonstrates more than 400-fold selectivity for Bcl-xL over Bcl-2, Mcl-1, Bcl-W, or A1. It has been shown to induce apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells. WEHI-539 can be used as a tool for distinguishing...
Keywords: | 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiaz... |
Application: | Bcl-xL inhibitor |
CAS | 1431866-33-9 |
MW: | 583.7 D |
From 77.00€
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Item number: Cay11499-5
Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...
Keywords: | GX15-070, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate |
Application: | Antagonist of Bcl-2 family members containing four Bcl-2 homology domains |
CAS | 803712-79-0 |
MW: | 413.5 D |
From 84.00€
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Item number: A300-284A
Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Keywords: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay22963-1
A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the...
Keywords: | 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)... |
Application: | BCL-XL inhibitor |
CAS | 1430844-80-6 |
MW: | 658.8 D |
From 130.00€
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Item number: ARG21415.50
Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Keywords: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X |
Application: | FC, IHC (paraffin), ICC, IF, WB, ELISA |
Host: | Mouse |
Species reactivity: | human, mouse, rat, rhesus monkey |
544.00€
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Item number: ARG21417.50
Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Keywords: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X |
Application: | FC, IHC (paraffin), ICC, IF, WB, ELISA |
Host: | Mouse |
Species reactivity: | human, mouse, rat, rhesus monkey |
592.00€
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Item number: ARG22305.50
Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Keywords: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X |
Application: | WB, IP, FC, IHC (paraffin), ELISA |
Host: | Mouse |
Species reactivity: | mouse, rat, human |
480.00€
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