Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-243A-T 20 µl (2 blots) -

3 - 9 business days*

A302-243A-M 100 µl (10 blots) -

3 - 9 business days*

A302-243A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Deubiquitinating enzyme that plays a key role in chromatin by mediating... more
Product information "Anti-BAP1"
Protein function: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor. [The UniProt Consortium]
Keywords: Anti-BAP1, Anti-hucep-6, Anti-KIAA0272, EC=, Anti-Cerebral protein 6, Anti-BRCA1-associated protein 1, Anti-Ubiquitin carboxyl-terminal hydrolase BAP1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-243A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Zebrafish, X. Tropicalis, Chicken, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-243A-T maps to a region between residue 679 and 729 of human BRCA1-associated protein 1 using the numbering given in entry NP_004647.1 (GeneID 8314).
Format: Antigen Affinity Purified

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