Anti-Aurora-B (human), Rabbit Monoclonal (RM278)

Recombinant Antibody. This antibody reacts to human Aurora kinase B. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.