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Human AURKB (Aurora Kinase B) ELISA Kit
Human AURKB (Aurora Kinase B) ELISA Kit

Item number: ELK-ELK4635.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AURKB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AURKB. Next,...
Keywords: STK-1, ARK-2, AURKB, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,...
Application: ELISA
Species reactivity: human
365.00€ * From 328.50€ *
Review
Chemi-Verse(TM) Aurora Kinase B Assay Kit
Chemi-Verse(TM) Aurora Kinase B Assay Kit

Item number: BPS-82094

The Chemi-Verse(TM) Aurora Kinase B Assay Kit is a luminescence assay designed to measure Aurora Kinase B kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant Aurora Kinase B, kinase...
Keywords: AURKB, STK-1, ARK-2, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,...
Application: Enzyme kinetics, kinase assay, small molecule inhibitor screening, drug discovery, HTS
Species reactivity: human
1,496.00€ *
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ZM 447439
ZM 447439

Item number: Cay13601-10

The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...
Keywords: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide
Application: Aurora B kinase inhibitor
CAS 331771-20-1
MW: 513.6 D
From 82.00€ *
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Anti-phospho-Aurora B (Thr232)
Anti-phospho-Aurora B (Thr232)

Item number: 600-401-677

Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced...
Keywords: Anti-phospho-AIK2, Anti-phospho-AURKB, Anti-phospho-ARK-2, Anti-phospho-STK-1, Anti-phospho-AIM-1, Anti-phospho-Aurora 1,...
Application: ELISA, IHC, IFM, WB
Host: Rabbit
Species reactivity: human
From 180.00€ *
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AMG 900
AMG 900

Item number: Cay19176-1

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively....
Keywords: N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
Application: Aurora kinase inhibitor
CAS 945595-80-2
MW: 503.6 D
From 60.00€ *
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Anti-Aurora B
Anti-Aurora B

Item number: A300-431A

Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced...
Keywords: Anti-AIK2, Anti-STK-1, Anti-AIM-1, Anti-AURKB, Anti-ARK-2, Anti-Aurora 1, EC=2.7.11.1, Anti-Aurora kinase B,...
Application: WB, IP, ICC-IF
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
Tozasertib
Tozasertib

Item number: SYN-1092-M001

Soluble in DMSO or ethanol. In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle...
Keywords: MK-0457, VX-680
Application: Aurora inhibitor
CAS 639089-54-6
MW: 464,6 D
From 66.00€ *
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Aurora Kinase B, active human recombinant protein
Aurora Kinase B, active human recombinant protein

Item number: BPS-40002

Active human Aurora kinase B (GenBank Accession No. NM_004217), (a.a. 2- 344), with N-terminal GST-HIS6-tag , expressed in a Baculovirus infected Sf9 cell expression system. The theoretical MW is 70 kDa.
Keywords: AURKB, STK-1, ARK-2, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,...
Application: Enzyme kinetics, inhibitor screening
MW: 70 kD
525.00€ *
Review
AZD 1152 (hydrochloride)
AZD 1152 (hydrochloride)

Item number: Cay13647-1

AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50 = 0.36 nM). AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis...
Keywords: Barasertib,...
Application: Aurora kinase B inhibitor prodrug
CAS 722543-50-2
MW: 660.5 D
From 32.00€ *
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Hesperadin
Hesperadin

Item number: Cay24199-1

Hesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays. Hesperadin (1 µM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and...
Keywords: N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide
Application: Multi-kinase inhibitor
CAS 422513-13-1
MW: 516.7 D
From 66.00€ *
Review
Danusertib
Danusertib

Item number: Cay18387-1

Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
Keywords: PHA-739358,...
Application: Aurora kinase inhibitor
CAS 827318-97-8
MW: 474.6 D
From 60.00€ *
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GSK1070916
GSK1070916

Item number: Cay22953-1

GSK1070916 is a potent and ATP-competitive inhibitor of Aurora kinases B and C (Kis = 0.38 and 1.5 nM, respectively). It is >250-fold selective for Aurora B and C over Aurora A. GSK1070916 inhibits proliferation of A549 lung cancer cells in vitro (EC50 = 7 nM). It also inhibits proliferation in a panel of 100 tumor...
Keywords: N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-...
Application: Aurora B/C kinase inhibitor
CAS 942918-07-2
MW: 507.6 D
From 54.00€ *
Review
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