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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
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*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG43219.100 | 100 µl | - | - |
6 - 14 business days* |
30 %
|
624.00€
436.80€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... more
Product information "Anti-ATR"
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex. {ECO:0000250, UniProtKB:Q9JKK8, ECO:0000269, PubMed:10597277, ECO:0000269, PubMed:10608806, ECO:0000269, PubMed:10859164, ECO:0000269, PubMed:11114888, ECO:0000269, PubMed:11418864, ECO:0000269, PubMed:11673449, ECO:0000269, PubMed:11721054, ECO:0000269, PubMed:11865061, ECO:0000269, PubMed:12526805, ECO:0000269, PubMed:12791985, ECO:0000269, PubMed:12814551, ECO:0000269, PubMed:14657349, ECO:0000269, PubMed:14729973, ECO:0000269, PubMed:14742437, ECO:0000269, PubMed:15210935, ECO:0000269, PubMed:15314022, ECO:0000269, PubMed:15496423, ECO:0000269, PubMed:16260606, ECO:0000269, PubMed:21144835, ECO:0000269, PubMed:27723717, ECO:0000269, PubMed:27723720, ECO:0000269, PubMed:9427750, ECO:0000269, PubMed:9636169, ECO:0000269, PubMed:9925639}. [The UniProt Consortium]
Keywords: | Anti-ATR, Anti-FRP1, Anti-FRAP-related protein 1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia telangiectasia and Rad3-related protein, Anti-Ataxia telangiectasia and Rad3-rel |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG43219 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant fusion protein corresponding to aa. 400-650 of Human ATR (NP_001175.2) |
MW: | 301 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06640 | Matching products |
UniProt ID : | Q13535 | Matching products |
Gene ID : | GeneID 545 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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