Anti-Apoptosis Inducing Factor (AIF)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
200-401-985	100 µg		-	-	6 - 10 business days*		834.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Probable oxidoreductase that has a dual role in controlling cellular life and... more

Close menu

Product information "Anti-Apoptosis Inducing Factor (AIF)"

Protein function: Probable oxidoreductase that has a dual role in controlling cellular life and death, during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. [The UniProt Consortium]

Keywords:	Anti-AIF, Anti-AIFM1, EC=1.-.-.-, Anti-Programmed cell death protein 8, Anti-Apoptosis-inducing factor 1, mitochondrial
Supplier:	Rockland Immunochemicals
Supplier-Nr:	200-401-985

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	synthetic peptide corresponding to amino acids near the carboxyl terminus of human AIF protein