Anti-AIF

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-783A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A302-783A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Functions both as NADH oxidoreductase and as regulator of apoptosis. In... more

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Product information "Anti-AIF"

Protein function: Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. [The UniProt Consortium]

Keywords:	Anti-AIF, Anti-AIFM1, EC=1.1.1.-, Anti-Programmed cell death protein 8, Anti-Apoptosis-inducing factor 1, mitochondrial
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-783A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat)
Immunogen:	synthetic peptide. The epitope recognized by A302-783A-T maps to a region between residue 563 and 613 of human Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 using the numbering given in entry NP_004199.1 (GeneID 9131).
Format:	Antigen Affinity Purified