Anti-APC

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-980A-T	10 µl (10 µg)		-		2 - 8 business days*		178.00€
A300-980A	100 µl (100 µg)		-		2 - 8 business days*		630.00€

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Protein function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt... more

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Product information "Anti-APC"

Protein function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. [The UniProt Consortium]

Keywords:	Anti-APC, Anti-DP2.5, Anti-Protein APC, Anti-Deleted in polyposis 2.5, Anti-Adenomatous polyposis coli protein
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-980A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: bovine, dog, horse, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, small-eared galago, little brown bat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-980A-T maps to a region between residue 75 and 125 of human adenomatosis polyposis coli using the numbering given in entry NP_000029.2 (GeneID 324).
Format:	Antigen Affinity Purified