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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32260-100 | 100 µl | - |
6 - 10 business days* |
525.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
alpha-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly... more
Product information "Anti-alpha-Tubulin K40Ac Rabbit Monoclonal Antibody (Clone RM318)"
alpha-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly that has roles in a variety of cellular processes, including cell motility, division, differentiation, and intracellular transport. alpha-Tubulin is highly conserved in eukaryotes and expressed in a cell- and isotype-specific manner. There are eight human alpha-tubulin isotypes that consist of an N-terminal domain, which binds GTP and is required for microtubule self-assembly, and a variable C-terminal tail, which contains interaction sites for microtubule-associated proteins (MAPs) and is subject to a variety of post-translational modifications that regulate microtubule function and stability. alpha-Tubulin can be acetylated at a variety of sites, including on the luminal side of microtubules at lysine 40 (K40Ac), by alpha-tubulin N-acetyltransferase 1 (alpha-TAT) and deacetylated primarily by histone deacetylase 6 (HDAC6). alpha-Tubulin K40Ac is a marker of stable microtubules that recruits dynein and kinesin-1 to microtubules. It is also involved in regulating microtubule architecture as well as immune and viral responses. The levels of alpha-tubulin acetylation are decreased in a variety of neurological disorders, increased in various cancers, and dysregulated in immune disorders. Cayman's alpha-Tubulin K40Ac Rabbit Monoclonal Antibody (Clone RM318) can be used for immunocytochemistry (ICC) and Western blot (WB) applications.Immunogen: Peptide corresponding to alpha-tubulin K40Ac. Clone Designation: RM318. Formulation: (Request formulation change), 100 µl of protein A-purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ICC, WB. Cross Reactivity: (+) alpha-Tubulin (K40Ac), (-) alpha-Tubulin without acetylation at K40.
Supplier: | Cayman Chemical |
Supplier-Nr: | 32260 |
Properties
Application: | ICC, WB |
Antibody Type: | Monoclonal |
Clone: | RM318 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | Peptide corresponding to ?-tubulin K40Ac |
Format: | Purified |
Database Information
KEGG ID : | K07374 | Matching products |
UniProt ID : | P68363 | Matching products |
Gene ID | GeneID 10376 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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