332 products were found matching "K07374"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TUBa4A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TUBa4A....

Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and...

Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and...

Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....

Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values...

Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]

Detects K40 acetylation of alpha-tubulin, signal specifically increased by modification with tubulin acetyl transferase alpha-TAT1. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule...

Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel (Cay-10461). It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM). In vivo, docetaxel inhibits tumor growth in several cancer models,...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Alpha Tubulin antibody detects Alpha tubulin, a fundamental structural component of microtubules, which are integral parts of the cytoskeleton responsible for cell shape, intracellular transport, and mitotic spindle formation. The UniProt...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Alpha Tubulin (acetyl K40) antibody detects alpha tubulin specifically when acetylated at lysine 40. Alpha tubulin, encoded by multiple genes including TUBA1A, TUBA3C, and TUBA4A, is one of the two...

Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 µM) that binds to tubulin, which disrupts spindle formation during mitosis. It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity...

Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]