332 products were found matching "K07374"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Alpha Tubulin antibody detects Alpha tubulin, a fundamental structural component of microtubules, which are integral parts of the cytoskeleton responsible for cell shape, intracellular transport, and mitotic spindle formation. The UniProt...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Alpha Tubulin (acetyl K40) antibody detects alpha tubulin specifically when acetylated at lysine 40. Alpha tubulin, encoded by multiple genes including TUBA1A, TUBA3C, and TUBA4A, is one of the two...

Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....

Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values...

Mertansine-13C-d3 is intended for use as an internal standard for the quantification of mertansine (Cay-22483) by GC- or LC-MS. Mertansine is a synthetic maytansinoid antimitotic agent. It is cytotoxic to KB epidermoid carcinoma and SK-BR-3 breast cancer cells (IC50 = 1. nM for both). Mertansine has commonly been...

Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]

Detects K40 acetylation of alpha-tubulin, signal specifically increased by modification with tubulin acetyl transferase alpha-TAT1. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule...

Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel (Cay-10461). It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM). In vivo, docetaxel inhibits tumor growth in several cancer models,...

Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 µM) that binds to tubulin, which disrupts spindle formation during mitosis. It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity...

Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]

Microtubule inhibitor, Antitumor compound, Mitosis inhibitor, Arrests the cell cycle at G2/M phase, Promotes tubulin depolymerization, Induces fragmentation of the Golgi complex, Inhibits the T cell antigen receptor, Stimulates the intrinsic GTPase activity of tubulin, Activates the JNK/SAPK signaling pathway,...

Nocodazole is an antimitotic agent. It increases tubulin GTP hydrolysis four-fold and induces tubulin depolymerization. Nocodazole (4 µg/ml) halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase. It also decreases neuronal mitochondrial transport and density in a transgenic...