Anti-Alpha 1 Antitrypsin / AAT / SERPINA1, clone AAT/1379

Anti-Alpha 1 Antitrypsin / AAT / SERPINA1, clone AAT/1379
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3222-20UG 20 µg - -

3 - 10 business days

NSJ-V3222-100UG 100 µg - -

3 - 10 business days

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Alpha-1 Antitrypsin... more
Product information "Anti-Alpha 1 Antitrypsin / AAT / SERPINA1, clone AAT/1379"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Alpha-1 Antitrypsin or alpha1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence (such as in alpha 1-antitrypsin deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non-functional proteins that can polymerise and accumulate in the liver (infantile hepatic cirrhosis). [Wiki] Protein function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. [The UniProt Consortium]
Keywords: Anti-AAT, Anti-PRO0684, Anti-SERPINA1, Alpha 1 Antitrypsin Antibody / AAT / SERPINA1
Supplier: NSJ Bioreagents
Supplier-Nr: V3222-20UG


Application: WB, IHC (paraffin), FC, IF
Antibody Type: Monoclonal
Clone: AAT/1379
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A human partial recombinant protein was used as the immunogen for this Alpha 1 Antitrypsin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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