Anti-AKT3, clone 154CT4.5.3

Anti-AKT3, clone 154CT4.5.3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F40227-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F40227-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. AKT3 is a member of the AKT, also called PKB,... more
Product information "Anti-AKT3, clone 154CT4.5.3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Protein function: AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. [The UniProt Consortium]
Keywords: Anti-PKBG, Anti-AKT3, Anti-STK-2, Anti-PKB gamma, EC=2.7.11.1, Anti-RAC-PK-gamma, Anti-Protein kinase Akt-3, Anti-Protein kinase B gamma, Anti-RAC-gamma serine/threonine-protein kinase, AKT3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F40227

Properties

Application: WB, IHC, ELISA
Antibody Type: Monoclonal
Clone: 154CT4.5.3
Conjugate: No
Host: Mouse
Species reactivity: human, mouse
Immunogen: This AKT3 antibody was produced from a mouse immunized with AKT3 recombinant protein.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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