562 products were found matching "K04456"!
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Anti-AKT3
Item number: ABS-KC-2766.100
Protein function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range...
| Keywords: | Anti-RAC-gamma serine/threonine-protein kinase, Anti-Protein kinase Akt-3, Anti-Protein kinase B gamma, Anti-PKB gamma,... |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Anti-AKT3
Item number: ABS-KC-3409.100
Protein function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range...
| Keywords: | Anti-RAC-gamma serine/threonine-protein kinase, Anti-Protein kinase Akt-3, Anti-Protein kinase B gamma, Anti-PKB gamma,... |
| Application: | IP |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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MK-2206 dihydrochloride
Item number: TGM-T1952-10mg
Description: MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor activity. Target: Apoptosis, Akt, Autophagy. Smiles:...
| Keywords: | MK-2206 2HCl |
| Application: | Allosteric Akt inhibitor |
| CAS | 1032350-13-2 |
| MW: | 480.39 D |
From 31.00€
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AKT-IN-1
Item number: TGM-T4489-100mg
Description: AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 µM). Target: Akt. Smiles: NC(=O)c1cnc(-c2ccc(cc2)C2(N)CCC2)c(c1)-c1ccccc1. References: Kettle JG, et al. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. J Med Chem. 2012 Feb 9,55(3):1261-73.
| Keywords: | AZD26, AZD-26, AZD 26 |
| Application: | AKT inhibitor |
| CAS | 1357158-81-6 |
| MW: | 343.42 D |
From 114.00€
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Ipatasertib
Item number: TGM-T6252-100mg
Description: Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively. Target: Akt. Smiles: C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3. References: Lin K. Cancer Res, 2011, 71(8 Supplement), abstract DDT02-01.
| Keywords: | GDC-0068, RG7440 |
| Application: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1001264-89-6 |
| MW: | 458 D |
From 40.00€
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Uprosertib
Item number: TGM-T6849-100mg
Description: Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2. Target: Akt. Smiles: Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)NC(CN)Cc1ccc(F)c(F)c1. References: Pachl F, et al. J Proteome...
| Keywords: | GSK2141795, GSK795 |
| Application: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1047634-65-0 |
| MW: | 429.25 D |
From 40.00€
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Miransertib mesylate
Item number: TGM-T70152-100mg
Description: Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in reduction in tumor cell proliferation and the induction of tumor cell apoptosis....
| Application: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1817727-88-0 |
| MW: | 624.73 D |
From 1,520.00€
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Afuresertib hydrochloride
Item number: TGM-T7885-100mg
Description: Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively). Target: PKC, ROCK, Akt. Smiles: Cl.Cn1ncc(Cl)c1-c1cc(sc1Cl)C(=O)N[C@H](CN)Cc1cccc(F)c1. References: Yamaji M , Ota A , Wahiduzzaman M , et al. Novel ATP-competitive Akt inhibitor afuresertib...
| Application: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1047645-82-8 |
| MW: | 463.8 D |
From 45.00€
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BAY1125976
Item number: TGM-T7315-100mg
Description: BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay). Target: Akt. Smiles: NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1. References: Politz O , Siegel F , Bärfacker L, et al. BAY 1125976, a selective allosteric AKT1/2...
| Application: | Allosteric Akt1/2 inhibitor |
| CAS | 1402608-02-9 |
| MW: | 383.45 D |
From 34.00€
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Borussertib
Item number: TGM-T8427-100mg
Description: Borussertib is a first-in-class covalent-allosteric inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Target: Akt. Smiles: C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1. References: Niklas Uhlenbrock, et al. Structural and...
| Application: | Akt1 / Akt2 inhibitor |
| CAS | 1800070-77-2 |
| MW: | 596.68 D |
From 134.00€
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API-1
Item number: TGM-T8969-100mg
Description: API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, beta-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . Target: Akt. Smiles: NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O. References: Ren H , Koo J , Guan B , et al. The E3...
| Keywords: | NSC177223 |
| Application: | AKT inhibitor |
| CAS | 36707-00-3 |
| MW: | 337.29 D |
From 77.00€
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(E)-Akt inhibitor-IV
Item number: TGM-T9393-100mg
Description: (E)-Akt inhibitor-IV ((E)-AKTIV) is an inhibitor of PI3K-Akt. Target: Akt. Smiles: CCN(C1/C=C/N(C)c2ccccc2)c(cc(cc2)-c3nc(cccc4)c4s3)c2N1c1ccccc1.I. References: Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to...
| Keywords: | CS-1992, (E)-AKTIV |
| Application: | PI3K-Akt inhibitor |
| CAS | 959841-49-7 |
| MW: | 616.56 D |
From 49.00€
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