Anti-Adropin (Clone CC1133F5)

Adropin is a 76 amino acid secreted peptide expressed in the brain, liver, and plasma and is encoded by the energy homeostasis associated gene. It is highly conserved in mammals, and is involved in glucose homeostasis and lipid metabolism. Plasma levels of adropin decrease with age and have been associated with metabolic disorders such as dyslipidemia and insulin resistance. Adropin is involved in post-transcriptional activation of eNOS, the up-regulation of VEGFR2, and activation of the ERK1/2 pathway. Adropin's involvement in endothelial cells results in increased proliferation and migration, and decreased permeability and apoptosis. Western blot detects adropin at 14-17 kDa in an over-expression cell lysate, and at 25 kDa for SUMO-tagged adropin recombinant protein.Synonyms: Energy Homeostasis-Associated Protein. Immunogen: Human adropin amino acids 34-76. Clone Designation: CC1133F5. Amino Acids: 34-76. Formulation: (Request formulation change), 200 µg of protein G-purified IgG. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, IHC, WB. UniProt Accession #: Q6UWT2.