Anti-Adiponectin

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31122 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Adiponectin, als called ADIPOQ... more
Product information "Anti-Adiponectin"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Adiponectin, als called ADIPOQ (Adipocyte-, C1q-, and Collagen Domain-Containing), APM1, ADPN and ACDC, is a protein which in humans is encoded by the ADIPOQ gene. Using FISH, Das et al.(2001) mapped the mouse Acrp30 gene to chromosome 16 in a region showing homology of synteny with human 3q27. By RNase protection and Western blot analysis, Schaffler et al.(1999) showed that ADIPOQ is expressed by differentiated adipocytes as a 30-kD protein that is also detectable in serum. By sequence comparisons, they found links between ADIPOQ and TNF family ligands as well as to cytokines expressed by T cells. It is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. It is exclusively secreted from adipose tissue(and also from the placenta in pregnancy) into the bloodstream and is very abundant in plasma relative to many hormones. Protein function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. [The UniProt Consortium]
Keywords: Anti-ACDC, Anti-apM-1, Anti-ADIPOQ, Anti-ACRP30, Anti-Adiponectin, Anti-Gelatin-binding protein, Anti-30 kDa adipocyte complement-related protein, Anti-Adipocyte complement-related 30 kDa protein, Anti-Adipose most abundant gene transcript 1 protein, Adip
Supplier: NSJ Bioreagents
Supplier-Nr: R31122

Properties

Application: WB, IHC (paraffin), IF, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: An amino acid sequence from the C-terminus of human ADIPOQ (LYADNDNDSTFTGFLLYHDTN) was used as the immunogen for this Adiponectin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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