Anti-ACTH (Adrenocorticotropic Hormone, Adrenocorticotropin)

Adrenocorticotropin (ACTH) occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin are endogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. ACTH can alter pain sensitivity. The effect of corticosteroids like ACTH on the sensitivity to pain is an indirect one by virtue of their negative feedback action on the hypothalamic-pituitary system. Applications: Suitable for use in Immunofluorescence, Immunohistochemistry (frozen), and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 5-10ug/ml (Immunofluorescence detection), Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.