Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14777-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognition of epigenetic marks can be mediated by small modular protein units of ~50 amino acids... more
Product information "UHRF1 PHD domain (human recombinant)"
Recognition of epigenetic marks can be mediated by small modular protein units of ~50 amino acids called Plant Homeodomain (PHD) fingers. PHD fingers are zinc binding domains that have a Cys4-His-Cys3 motif and are found in more than 100 nuclear proteins that play a role in regulating chromatin. PHD domains often work with other protein regions, such as bromodomains and Tudor domains, to recognize post-translational modifications in many proteins. Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a multidomain-containing nuclear protein known to bind chromatin and participate in the maintenance of DNA methylation. The SET and RING associated domain of UHRF1, also called the YDG motif, binds methyl cytosines, while trimethylated histone H3 lysine 9 (H3K9me3) and unmethylated histone H3 Arginine 2 (H3R2me0) are recognized by the tandem Tudor-like domains and the PHD domain, respectively. Some evidence suggests the tandem Tudor-like region and adjacent PHD domain may operate together to recognize H3K9me3. The combinatorial recognition of the histone tail region and hemi-methylated DNA functions to regulate gene silencing by directly interacting with DNA (cytosine-5)-methyltransferase 1. UHRF1 also posseses E3 ubiquitin ligase activity toward histone H3 and the tumor suppressor promyelocytic leukemia protein. This protein product contains the PHD finger region of UHRF1.Synonyms: E3 Ubiquitin-protein Ligase UHRF1, Inverted CCAAT Box Binding Protein of 90 kDa, Nuclear Protein 95, RING Finger Protein 106, Transcription Factor ICBP90, Ubiquitin-like PHD and RING Finger Domain-containing Protein 1. Purity: >95%. Source: recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 298-366. MW: 35.5 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q96T88.
Keywords: | UHRF1, hNp95, hNp95, ICBP90, HuNp95, hUHRF1, HuNp95, hUHRF1, Nuclear protein 95, Nuclear protein 95, RING finger protein 106, RING finger protein 106, Transcription factor ICBP90, Transcription factor ICBP90, Nuclear zinc finger protein Np95, Nuclear zinc |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14777 |
Properties
Application: | Binding assays |
Conjugate: | No |
Host: | E.coli |
MW: | 35,5 kD |
Purity: | >95% |
Format: | Solution |
Database Information
KEGG ID : | K10638 | Matching products |
UniProt ID : | Q96T88 | Matching products |
Gene ID | GeneID 29128 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H319 |
P Phrases: | P264, P280, P305+351+338, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed