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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10783-100 | 100 µg | - |
6 - 10 business days* |
661.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to... more
Product information "TIP60 (human, recombinant)"
TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase. As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription. In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone gammaH2AX allows formation of the gammaH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of beta-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer's disease pathogenesis.Synonyms: cPLA(2) Interacting Protein, Esa1, Histone acetyltransferase KAT5, HIV-1 Tat Interacting Protein 60 kDa, Hs.6364, HTATIP, KAT5, PLIP. Purity: >50%. Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells. Amino Acids: 2-513 (Full length, Isoform 2). MW: 60.3 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol. UniProt Accession #: Q92993.
Keywords: | KAT5, Tip60, Tip60, HTATIP, Lysine acetyltransferase 5, Lysine acetyltransferase 5, cPLA(2)-interacting protein, cPLA(2)-interacting protein, HIV-1 Tat interactive protein, HIV-1 Tat interactive protein, Histone acetyltransferase KAT5, 60 kDa Tat-interact |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10783 |
Properties
Application: | Enzyme activity |
Conjugate: | No |
MW: | 60,3 kD |
Purity: | >50% |
Format: | Solution |
Database Information
KEGG ID : | K11304 | Matching products |
UniProt ID : | Q92993 | Matching products |
Gene ID | GeneID 10524 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
P Phrases: | P264, P305+P351+P338, P332+P313, P337+P313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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