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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-8618-10 | 10 µg | - | - |
3 - 11 business days* |
463.00€
|
||
ABE-32-8618-50 | 50 µg | - | - |
3 - 11 business days* |
695.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source: Human Cells. MW :49.4kD. Recombinant Human NKG2D ligand 1 is produced by our Mammalian... more
Product information "Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 (C-Fc)"
Source: Human Cells. MW :49.4kD. Recombinant Human NKG2D ligand 1 is produced by our Mammalian expression system and the target gene encoding Gly26-Pro215 is expressed with a Fc tag at the C-terminus. NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess a1, a2 and a3 domains, ULBP/RAET1 family members lack a3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the immune surveillance. ULBP1 and several other family members, ULBP2 and ULBP5, own the ability to bind the human cytomegalovirus (CMV) UL16 glycoprotein. The human CMV glycoprotein UL16 binds to intracellular ULBP1 and so inhibits its expression at the cell surface, which reduces the susceptibility of the virus-infected cell to cytotoxic destruction by NK cells. The expression of ULBP1 has been found on some tumor cells and is implicated in tumor surveillance. Protein function: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-8618 |
Properties
Conjugate: | No |
Database Information
KEGG ID : | K07986 | Matching products |
UniProt ID : | Q9BZM6 | Matching products |
Gene ID | GeneID 80329 | Matching products |
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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