Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P9400-10B.10 | 10 µg | - | - |
3 - 19 business days* |
955.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Proline-rich/Ca2+-activated tyrosine kinase (Pyk2) is a member of the FAK family of non-receptor,... more
Product information "Pyk2, Recombinant, Human, N-terminal GST tag (CAKbeta, cdk-activating Protein Kinase beta)"
Proline-rich/Ca2+-activated tyrosine kinase (Pyk2) is a member of the FAK family of non-receptor, proline-rich protein tyrosine kinases. Pyk2 signaling is initiated by a variety of extracellular stimuli including integrin ligation, CD surface marker ligation (e.g., CD3, CD28, TCR, VCAM), bioactive peptides, growth factors, cytokines, chemokines and certain stress stimuli (reactive oxygen species and Ca++ flux). Pyk2 is involved in the regulation of vesicular transport, osteoclastic bone resorption, modulation of ion channels, T- and B-cell receptor signaling and cell death. Pyk2 tyrosine 402 is autophosphorylated, an important initial step for full activation of the kinase. This phosphorylation also allows binding of Src and the p85 subunit of PI3-kinase. Human PYK2 (GenBank Accession No. U33284), full length with N-terminal His tag , MW 120kD, expressed in an Baculovirus infected Sf9 cell expression system. Specific Activity: 20 U/mg. One unit is defined as the amount of enzyme that will incorporate 1nmol phosphate to the tyrosine substrate at pH 7.4 and 30 °C. , Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3uM Na orthovanadate, 0.5 mM ATP, 30 ug/ml Poly (Glu:Tyr)4:1 substrate, and 0.04ug recombinant Pyk2, Application: useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. , Stability: >6 months at -80 °C
Keywords: | FAK2, CAKB, CADTK, PTK2B, RAFTK, FADK 2, CAK-beta, EC=2.7.10.2, Focal adhesion kinase 2, Cell adhesion kinase beta, Proline-rich tyrosine kinase 2, Protein-tyrosine kinase 2-beta, Calcium-dependent tyrosine kinase, Related adhesion focal tyrosine kinase |
Supplier: | United States Biological |
Supplier-Nr: | P9400-10B |
Properties
Conjugate: | No |
Species reactivity: | human |
MW: | 12 kD |
Database Information
KEGG ID : | K05871 | Matching products |
UniProt ID : | Q14289 | Matching products |
Gene ID | GeneID 2185 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed