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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
374619.20 | 20 µg | - | - |
3 - 19 business days* |
511.00€
|
||
374619.100 | 100 µg | - | - |
3 - 19 business days* |
773.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a... more
Product information "PARP1, Recombinant, Human, aa2-331, His-Tag (Poly [ADP-ribose] Polymerase 1)"
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Source: Recombinant protein corresponding to aa2-331 from human PARP1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~41kD, AA Sequence: AESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRK, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | ARTD1, PARP-1, ADPRT 1, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+) ADP-ribosyltransferase 1, DNA ADP-ribosyltransferase PARP1, Protein poly-ADP-ribosyltransferase PARP1, ADP-ribosyltransferase diphtheria toxin-like 1 |
Supplier: | United States Biological |
Supplier-Nr: | 374619 |
Properties
Conjugate: | No |
MW: | 41 |
Format: | Highly Purified |
Database Information
KEGG ID : | K10798 | Matching products |
UniProt ID : | P09874 | Matching products |
Gene ID | GeneID 142 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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