PAF Acetylhydrolase (human, recombinant)

Platelet-activating factor (PAF) is an important lipid mediator involved in inflammation. PAF-acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids. Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level. Cayman's PAF-AH is the secreted calcium-independent isoform. PAF deacetylation by PAF-AH causes loss of biological activity, making PAF-AH potentially useful as an anti-inflammation therapy.Synonyms: Group-VIIA phospholipase A2, LDL-PLA(2), Lipoprotein PLA2, PAF-AH, PLA2G7, gVIIA-PLA2, Lp-PLA2, Platelet-activating Factor Acetylhydrolase. Purity: >80% estimated by SDS-PAGE. Source: Active recombinant N-terminal hexahistidine-tagged protein expressed in E. coli. Amino Acids: 42-441 (full-length). MW: 46.4 kDa. Formulation: (Request formulation change), 50 mM sodium phosphate, pH 7.2, 100 mM NaCl, 10% glycerol. UniProt Accession #: Q13093.