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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10786-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline... more
Product information "PAD3 (human, recombinant)"
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, which include S100A3, trichohyalin, and filaggrin, resulting in the loss of a positive charge, which can alter protein structure and/or function. It exists as a homodimer and is composed of a C-terminal catalytic domain and an N-terminal domain that contains two immunoglobulin G (IgG) subdomains. PAD3 is primarily expressed by differentiated keratinocytes in the epidermis and hair follicles where it has roles in the shaping and mechanical strengthening of hair. It is also expressed by neural stem cells where it modulates cell death by regulating the nuclear translocation of apoptosis-inducing factor (AIF), in mammary glands where it citrullinates proteins during lactation, and cancer cells where it promotes cancer cell invasion. Mutations in PADI3 are associated with uncombable hair syndrome. Cayman's PAD3 (human, recombinant) protein can be used for enzyme activity assays.Synonyms: PADI3, PDI3, Peptidylarginine Deiminase 3, Protein Arginine Deiminase 3. Purity: >85% estimated by SDS-PAGE. Source: Active recombinant human N-terminal His-tagged PAD3 protein expressed in E. coli. Amino Acids: 2-664 (full length). MW: 76.4 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, containing 300 mM sodium chloride, 1 mM DTT, and 10% glycerol. UniProt Accession #: Q9ULW8.
Keywords: | PAD3, PADI3, Peptidylarginine deiminase III, Peptidylarginine deiminase III, Protein-arginine deiminase type-3, Protein-arginine deiminase type-3, Protein-arginine deiminase type III, Protein-arginine deiminase type III |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10786 |
Properties
Application: | Enzyme activity |
Conjugate: | No |
Purity: | >85% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K01481 | Matching products |
UniProt ID : | Q9ULW8 | Matching products |
Gene ID | GeneID 51702 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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