Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay35438-20 | 20 µg | - | - |
6 - 10 business days* |
204.00€
|
||
Cay35438-100 | 100 µg | - | - |
6 - 10 business days* |
489.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Matrix metalloproteinase-1 (MMP-1) is an endopeptidase that has a major role in tissue... more
Product information "MMP-1 (human, recombinant)"
Matrix metalloproteinase-1 (MMP-1) is an endopeptidase that has a major role in tissue remodeling. It is composed of an N-terminal extracellular signal peptide, a prodomain containing a cysteine switch that interacts with the catalytic domain to regulate the proteolytic activity of MMP-1, a catalytic domain, and a C-terminal domain containing four hemopexin-like repeats which confer specificity for collagen. MMP-1 is ubiquitously expressed at low levels under normal physiological conditions and localizes to the extracellular space. It is primarily involved in the degradation of the extracellular matrix with type I collagen being its main substrate, but also degrades types II, III, V, IX, and X fibrillar collagens. MMP-1 also cleaves cell surface molecules such as insulin-like growth factor 1 (IGF-1) binding protein 3 (IGFBP3) and TNF-alpha. Knockdown of MMP1 inhibits the proliferation, migration, and invasion of colorectal cancer cells. MMP1 transgenic mice exhibit increased alveolar damage following exposure to M. tuberculosis. Polymorphisms of MMP1 are associated with several diseases, including various cancers, periodontitis, and coronary artery disease. Cayman's MMP-1 (human, recombinant) protein can be used for enzyme activity applications. This protein consists of 461 amino acids and has a predicted N-terminus of Phe20 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 50-55 kDa.Synonyms: Collagenase-1, Fibroblast Collagenase, Interstitial Collagenase, Matrix Metalloproteinase-1. Purity: >96% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg determined by the LAL endotoxin assay. Source: Active recombinant human C-terminal His-tagged MMP-1 expressed in HEK293 cells. Amino Acids: 20-469. MW: 50-55 kDa. Formulation: (Request formulation change), Lyophilized from sterile 25 mM MES, pH 5.5, with 10 mM calcium chloride, 150 mM sodium chloride, and 0.05% Brij 35. UniProt Accession #: P03956.
Keywords: | CLG, MMP1, MMP-1, Fibroblast collagenase, Interstitial collagenase, Matrix metalloproteinase-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 35438 |
Properties
Application: | Active enzyme |
Conjugate: | No |
Host: | Human cells |
Purity: | >96% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K01388 | Matching products |
UniProt ID : | P03956 | Matching products |
Gene ID | GeneID 4312 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed