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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay40372-100 | 100 µg | - | - |
6 - 10 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
K-Ras is a small GTPase and member of the RAS family of GTPases with roles in apoptosis, as well... more
Product information "K-Ras(G12D) Isoform A (human, recombinant)"
K-Ras is a small GTPase and member of the RAS family of GTPases with roles in apoptosis, as well as cell proliferation, survival, and migration. K-Ras is composed of a guanine nucleotide-binding domain containing an active site, an effector binding domain, and an isoform-specific C-terminal hypervariable region (HVR) that differs between K-Ras isoforms A and B due to alternative splicing. The active site cycles between GDP-bound inactive and GTP-bound active states and is regulated by its associations with GTPase-activating proteins (GAPs) or guanine nucleotide exchange factors (GEFs). K-Ras is ubiquitously expressed and is tethered to the intracellular side of cell membranes via farnesyl and palmitoyl lipidation and to negatively charged or neutral regions of the membrane via a single polybasic region in the HVR. K-Ras(G12D), which contains a glycine-to-aspartic acid substitution at position 12, is constitutively active and associated with pancreatic, colon, and lung cancers. Inhibition of K-Ras(G12D) with the inhibitory peptide KS-58 reduces tumor volume in a PANC-1 pancreatic cancer mouse xenograft model. Tumor levels of K-Ras(G12D) are increased in patients with lung adenocarcinoma who had never smoked. Cayman's K-Ras(G12D) Isoform A (human, recombinant) protein consists of 185 amino acids and has a calculated molecular weight of 23 kDa.Synonyms: c-K-ras(G12D), c-Ki-ras(G12D), K-Ras4A(G12D), Ki-Ras(G12D), Kirsten Rat Sarcoma Virus(G12D), KRAS(G12D). Purity: >90%. Source: Recombinant human N-terminal His-tagged K-Ras(G12D) isoform A expressed in E. coli. Amino Acids: 2-186. MW: 23 kDa. Formulation: (Request formulation change), 20 mM HEPES, pH 7.4, 150 mM sodium chloride, 10% glycerol, and 1 mM dithiothreitol. UniProt Accession #: P01116.
Keywords: | KRAS, KRAS2, Ki-Ras, K-Ras 2, c-K-ras, c-Ki-ras, GTPase KRas, GTPase KRas, N-terminally processed |
Supplier: | Cayman Chemical |
Supplier-Nr: | 40372 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 23 kD |
Purity: | >90% |
Format: | Solution |
Database Information
KEGG ID : | K07827 | Matching products |
UniProt ID : | P01116 | Matching products |
Gene ID | GeneID 3845 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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