300 products were found matching "K07827"!

Protein function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor...

The Molecular Glue/PROTAC(R) Optimization Kit for KRAS (G12D) is an AlphaLISA(R) assay designed for the testing and profiling of Molecular Glues (MG) and PROTACs (proteolysis targeting chimera) targeting KRAS (G12D) (Kirsten rat sarcoma mutation G12D). The kit comes with enough recombinant KRAS (G12D), biotinylated...

AZD 0022 is an inhibitor of mutant K-RasG12D, the dominant K-Ras mutant in pancreatic ductal adenocarcinoma (PDAC).. SMILES: F[C@@H]1C[C@]2(COC3=NC(N4CC(N5)C=CC5C4)=C6C=C(F)[C@@]([C@@]7=CC(N)=CC(C=C8)=C7C(C#C)=C8F)=C(F)C6=N3)CCCN2C1. InChi Code:...

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...

A covalent K-RasG12C inhibitor (IC50 = 1.6 nM), inhibits ERK phosphorylation in K-RasG12C-expressing NCI H358 non-small cell lung cancer (NSCLC) cells (IC50 = 7.3 nM) and reduces their viability (IC50 = 23 nM), inhibits tumor growth in an NCI H1373 NSCLC mouse xenograft model at 10 mg/kg. SMILES:...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Small GTPases are a super-family of cellular signaling regulators. Ras belongs to the Ras sub-family of GTPases that regulate cell proliferation, cell motility, and gene transcription. GTP binding increases the...

KRAS, a Ras protein, binds GDP/GTP and possesses intrinsic GTPase activity, It plays an important role in the regulation of cell proliferation and in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

BI-2493 is an inhibitor of mutant K-Ras. It selectively decreases the proliferation of Ba/F3 cells expressing K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C), K-RasG12D, or K-RasG12V (EC50s = 118, 52, and 81 nM, respectively) over Ba/F3 cells expressing H-Ras or N-Ras (EC50s = 2,359...

(±)-Olomorasib is a racemic mixture of the oncogenic K-RasG12C inhibitor olomorasib and its optical isomer. Formal Name: (4R)-2-amino-4-[(4aS)-8-chloro-10-fluoro-2,3,4,4a,5,6-hexahydro-12-oxo-3-(1-oxo-2-propen-1-yl)-1H,12H-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluoro-benzo[b]thiophene-3-carbonitrile. CAS Number:...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G12D) is one type of Ras missense mutations at the codon 12. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G12D mutation results in...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G13D) is one type of Ras missense mutations at the codon 13. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G13D mutation results in...

ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4). It decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells, an effect that is enhanced by alpha-eleostearic acid (9(Z),11(E),13(E)-octadecatrienoic acid, Cay-10008349). ML-162 is also selectively lethal...