296 products were found matching "K07827"!

BI-2493 is an inhibitor of mutant K-Ras. It selectively decreases the proliferation of Ba/F3 cells expressing K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C), K-RasG12D, or K-RasG12V (EC50s = 118, 52, and 81 nM, respectively) over Ba/F3 cells expressing H-Ras or N-Ras (EC50s = 2,359...

(±)-Olomorasib is a racemic mixture of the oncogenic K-RasG12C inhibitor olomorasib and its optical isomer. Formal Name: (4R)-2-amino-4-[(4aS)-8-chloro-10-fluoro-2,3,4,4a,5,6-hexahydro-12-oxo-3-(1-oxo-2-propen-1-yl)-1H,12H-pyrazino[2,1-d][1,5]benzoxazocin-9-yl]-7-fluoro-benzo[b]thiophene-3-carbonitrile. CAS Number:...

A covalent K-RasG12C inhibitor (IC50 = 1.6 nM), inhibits ERK phosphorylation in K-RasG12C-expressing NCI H358 non-small cell lung cancer (NSCLC) cells (IC50 = 7.3 nM) and reduces their viability (IC50 = 23 nM), inhibits tumor growth in an NCI H1373 NSCLC mouse xenograft model at 10 mg/kg. SMILES:...

KRAS, a Ras protein, binds GDP/GTP and possesses intrinsic GTPase activity, It plays an important role in the regulation of cell proliferation and in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...

Garsorasib is an inhibitor of K-Ras containing the activating glycine-to-cysteine mutation at position 12 (K-RasG12C, IC50 = 18 nM). It selectively binds to GDP-bound K-RasG12C over GDP-bound wild-type K-Ras in thermal shift assays and selectively inhibits ERK phosphorylation in NCI H358 cells, which express...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Small GTPases are a super-family of cellular signaling regulators. Ras belongs to the Ras sub-family of GTPases that regulate cell proliferation, cell motility, and gene transcription. GTP binding increases the...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G12D) is one type of Ras missense mutations at the codon 12. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G12D mutation results in...

Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Ras (G13D) is one type of Ras missense mutations at the codon 13. Ras protein is a membrane-associated GTPase that regulates cell proliferation, differentiation, and survival. Ras G13D mutation results in...

ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4). It decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells, an effect that is enhanced by alpha-eleostearic acid (9(Z),11(E),13(E)-octadecatrienoic acid, Cay-10008349). ML-162 is also selectively lethal...

MRTX-1133 is an inhibitor of K-RasG12D, a mutant form of K-Ras that accumulates in cancer cells. It selectively reduces ERK phosphorylation in AsPC-1 cells expressing mutant K-RasG12D (IC50 = 10.8 nM) over MiaPaCa-2 and SW620 cells expressing mutant K-RasG12C or K-RasG12V (IC50s = 456 and 4,400 nM, respectively) and...

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM,...