Irisin:Fc, Recombinant, Human (Fibronectin Type III Domain-containing Protein 5, Fibronectin Type II

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. AA Sequence: aa16-127 of human Irisin fused at the C-terminus to the Fc portion of human IgG1. Species Homology: aa16-127 of human Irisin corresponds to aa29-140 of mouse Irisin. Irisin has 100% identity betwen mouse, rat, monkey and human. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.