Histone H4 (human, recombinant, His-tagged)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications (PTMs), such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Histone H4 PTMs function as epigenetic regulators of transcription by affecting chromatin structure and enhancing transcription factor binding, as well as play a key role in the maintenance of genomic integrity. Levels of histone H4 are increased in the inferior and middle temporal gyrus in postmortem brains from patients with Alzheimer's disease.Purity: >80% estimated by SDS-PAGE. Source: Recombinant human N-terminal His-tagged histone H4 expressed in E. coli. Amino Acids: 1-103. MW: 13.4 kDa. Formulation: (Request formulation change), A solution in water. UniProt Accession #: P62805.