CD279 [PD-1] (human):Fc (human) (rec.) (non-lytic)

CD279 [PD-1] (human):Fc (human) (rec.) (non-lytic)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-220PD1-C200 200 µg - -

3 - 9 business days*

484.00€
 
The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc... more
Product information "CD279 [PD-1] (human):Fc (human) (rec.) (non-lytic)"
The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the CD279 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Keywords: PD1, CD279, PDCD1, hPD-1, Protein PD-1, Programmed cell death protein 1
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-220PD1

Properties

Application: Bioassays
Conjugate: No
Expressed in: Hamster cells
Origin: Human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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