CD279 [PD-1] (human) (rec.) (His)

CD279 [PD-1] (human) (rec.) (His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-201PD1-C100 100 µg - -

3 - 9 business days*

396.00€
 
CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the... more
Product information "CD279 [PD-1] (human) (rec.) (His)"
CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Protein function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. [The UniProt Consortium]
Keywords: PD1, CD279, PDCD1, hPD-1, Protein PD-1, Programmed cell death protein 1
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-201PD1

Properties

Application: ELISA
Conjugate: No
Expressed in: Human cells
Origin: Human
MW: ~30 kD
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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