CD279 [PD-1] (human):Fc (mouse) (rec.)

CD279 [PD-1] (human):Fc (mouse) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-211PD1-C100 100 µg - -

3 - 9 business days*

CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the... more
Product information "CD279 [PD-1] (human):Fc (mouse) (rec.)"
CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Keywords: PD1, PDCD1, CD279, hPD-1, Protein PD-1, Programmed cell death protein 1, PD-1, Programmed Cell Death Protein 1
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-211PD1


Application: Bioassays
Conjugate: No
Expressed in: Human cells
Origin: Human
MW: ~60 kD
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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