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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32562-10 | 10 µg | - |
6 - 10 business days* |
760.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Poly(ADP-Ribose) polymerase 2 (PARP2) is an ADP-ribosylating enzyme with a role in the DNA damage... more
Product information "Anti-PARP2 (human, recombinant)"
Poly(ADP-Ribose) polymerase 2 (PARP2) is an ADP-ribosylating enzyme with a role in the DNA damage response (DRR). It is composed of a natively disordered N-terminal region containing a nuclear localization sequence, a central Trp-Gly-Arg (WGR) domain that is essential to DNA damage-dependent catalytic domain activity, and a C-terminal catalytic domain (CAT) that contains an ADP-ribosyltransferase fold and a regulatory helical subdomain. PARP2 is ubiquitously expressed and localized to the nucleus where it is preferentially activated by the presence of PARP1-induced poly(ADP)-ribosylation (PARylation) induced by PARP1 (Cay-32561) at sites of single-stranded DNA breaks. The WGR domain binds directly to DNA and activates PAR catalytic activity and branched PAR chain synthesis through cross-talk with the helical subdomain. PARP2 PARylates itself and other proteins, including transcription factors, influencing multiple biological processes, such as transcription, genome maintenance, and cell signaling. PARP2 expression is negatively correlated with the amount of tumor immune infiltrate in tumor samples isolated from patients with osteosarcoma. Cayman's PARP2 (human, recombinant) protein can be used for enzyme assay applications. This protein consists of 582 amino acids and has a calculated molecular weight of 95.5 kDa.Synonyms: ADPRT, ADPRT2, ADPRTL2, ARTD2, Poly (ADP-ribose) Polymerase 2, Poly(ADP-ribosyl)transferase 2. Purity: >50% estimated by SDS-PAGE. Source: Active recombinant human N-terminal GST-tagged PARP2 expressed in insect cells. Amino Acids: 2-583 (full length). MW: 95.5 kDa. Formulation: (Request formulation change), 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 16 mM glutathione, 20% glycerol, and 3 mM DTT. Host: Insect cells. UniProt Accession #: Q9UGN5.
Keywords: | PARP2, ARTD2, ARTD2, ADPRT2, PARP-2, PARP-2, hPARP-2, ADPRT-2, hPARP-2, ADPRT-2, pADPRT-2, pADPRT-2, Poly[ADP-ribose] synthase 2, Poly[ADP-ribose] synthase 2, Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase 2, NAD(+) ADP-ribosyltransferase 2, |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32562 |
Properties
Application: | Enzyme assay |
Conjugate: | No |
Host: | Insect cells |
Purity: | >50% estimated by SDS-PAGE |
Format: | Partially Purified |
Database Information
KEGG ID : | K10798 | Matching products |
UniProt ID : | Q9UGN5 | Matching products |
Gene ID | GeneID 10038 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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