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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24543-1 | 1 mg | - |
6 - 10 business days* |
114.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell... more
Product information "Neuromedin B (trifluoroacetate salt)"
Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor). It displays similar affinity for frog [Phe13]bombesin receptors (Ki = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (Kis = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice. NMB (50 µg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function. In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle.Formal Name: glycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl-L-methioninamide, 2,2,2-trifluoroacetate. Synonyms: NMB. Molecular Formula: C52H73N15O12S . XCF3COOH. Formula Weight: 1132.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC(CN[H])=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCSC)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C52H73N15O12S.C2HF3O2/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5,3-2(4,5)1(6)7/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73),(H,6,7)/t28-,29+,35-,36-,37-,38-,39-,40-,44-,/m0./s1. InChi Key: RATZXJUGJPBSDM-XVRGBKBISA-N.
Keywords: | NMB, glycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl-L-methioninamide, 2,2,2-trifluoroacetate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24543 |
Properties
Application: | NMB receptor agonist |
Conjugate: | No |
MW: | 1132.3 D |
Formula: | C52H73N15O12S . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K05223 | Matching products |
UniProt ID : | P08949 | Matching products |
Gene ID | GeneID 4828 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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