MMG-11

MMG-11 is an antagonist of the toll-like receptor 1/2 (TLR1/2) heterodimer (IC50 = 0.9 µM in HEK-Blue cells expressing the human receptors). It is selective for TLR1/2 over the TLR2/6 heterodimer (IC50 = 7.4 µM in HEK-Blue cells expressing the human receptors). MMG-11 inhibits TNF-alpha and IL-6 cytokine secretion induced by the bacterial lipopeptide agonist of TLR2, Pam3CKS4 (Cay-24126), in RAW 264.7 macrophages (IC50s = 3.3 and 0.2 µM, respectively). It increases serotonin transporter (SERT) and glutathione (GSH) activity, as well as decreases lactate dehydrogenase (LDH) activity and malondialdehyde (MDA) levels, in M. avium-infected Caco-2 cells when used at a concentration of 5 ng/ml.Formal Name: 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-2-furancarboxylic acid. CAS Number: 313254-94-3. Molecular Formula: C15H14O7. Formula Weight: 306.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. lambdamax: 216, 245, 263, 299 nm. SMILES: OC1=C(O)C(O)=C(C(CC2=CC=C(C(OCC)=O)O2)=O)C=C1. InChi Code: InChI=1S/C15H14O7/c1-2-21-15(20)12-6-3-8(22-12)7-11(17)9-4-5-10(16)14(19)13(9)18/h3-6,16,18-19H,2,7H2,1H3. InChi Key: IIDUJWIVMGALOG-UHFFFAOYSA-N.