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Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has... more
Product information "Malformin A"
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells. Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells. It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.Formal Name: cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl), cyclic (1->2)-disulfide. CAS Number: 3022-92-2. Synonyms: Malformin A1. Molecular Formula: C23H39N5O5S2. Formula Weight: 529.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml. SMILES: O=C1[C@@]([C@@H](C)CC)([H])NC([C@@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H]2NC([C@@H](CSSC2)N1)=O)=O)=O)=O. InChi Code: InChI=1S/C23H39N5O5S2/c1-7-13(6)18-23(33)26-15-9-34-35-10-16(25-20(15)30)21(31)27-17(12(4)5)22(32)24-14(8-11(2)3)19(29)28-18/h11-18H,7-10H2,1-6H3,(H,24,32)(H,25,30)(H,26,33)(H,27,31)(H,28,29)/t13-,14+,15+,16+,17-,18-/m0/s1. InChi Key: RNCGDQLZIATDOU-ZDRBWGSPSA-N. Origin: Synthetic.
Keywords: | Malformin A1, cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl), cyclic (1->2)-disulfide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 27510 |
Properties
Application: | Bioactive cyclopentapeptide fungal metabolite |
Conjugate: | No |
MW: | 529.7 D |
Formula: | C23H39N5O5S2 |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 3022-92-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H301, H311, H331 |
P Phrases: | P261, P264, P270, P271, P280, P311, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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