Indolicidin (trifluoroacetate salt)

Indolicidin is an antimicrobial peptide. It is active against multidrug-resistant isolates of enteroaggregative E. coli (MDR-EAEC, MICs = 32 µM for all). Indolicidin is also active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively) and reduces viral replication of HIV-1 in MT-2 cells when used at concentrations ranging from 67 to 100 µg/ml., In vivo, indolicidin increases survival of MDR-EAEC-infected G. mellonella larvae.Formal Name: L-isoleucyl-L-leucyl-L-prolyl-L-tryptophyl-L-lysyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-argininamide, trifluoroacetate salt. Synonyms: ILPWKWPWWPWRR-NH2. Molecular Formula: C100H132N26O13 . XCF3COOH. Formula Weight: 1906.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 272 nm. SMILES: NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCN3C([C@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@@H]8CCCN8C([C@H](CC9=CNC%10=C9C=CC=C%10)NC([C@H](CCCCN[H])NC([C@H](CC%11=CNC%12=C%11C=CC=C%12)NC([C@@H]%13CCCN%13C([C@@H](NC([C@](N[H])([H])[C@@H](C)CC)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C100H132N26O13.C2HF3O2/c1-5-57(4)85(102)95(136)123-79(45-56(2)3)96(137)124-42-20-36-82(124)92(133)118-76(46-58-51-110-68-28-11-6-23-63(58)68)89(130)116-74(33-16-17-39-101)88(129)121-80(49-61-54-113-71-31-14-9-26-66(61)71)97(138)125-43-21-38-84(125)94(135)120-78(48-60-53-112-70-30-13-8-25-65(60)70)91(132)122-81(50-62-55-114-72-32-15-10-27-67(62)72)98(139)126-44-22-37-83(126)93(134)119-77(47-59-52-111-69-29-12-7-24-64(59)69)90(131)117-75(35-19-41-109-100(106)107)87(128)115-73(86(103)127)34-18-40-108-99(104)105,3-2(4,5)1(6)7/h6-15,23-32,51-57,73-85,110-114H,5,16-22,33-50,101-102H2,1-4H3,(H2,103,127)(H,115,128)(H,116,130)(H,117,131)(H,118,133)(H,119,134)(H,120,135)(H,121,129)(H,122,132)(H,123,136)(H4,104,105,108)(H4,106,107,109),(H,6,7)/t57-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,/m0./s1. InChi Key: HQRSBAXSXVGIBJ-MSEKKQLVSA-N.