Gly-Phe-beta-naphthylamide

Gly-Phe-beta-naphthylamide
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14634-50 50 mg -

1 - 10 business days

57.00€
Cay14634-100 100 mg -

1 - 10 business days

85.00€
Cay14634-500 500 mg -

1 - 10 business days

394.00€
 
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively... more
Product information "Gly-Phe-beta-naphthylamide"
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins. Gly-Phe-beta-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-beta-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. At 50 µM, Gly-Phe-beta-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.
Keywords: H-Gly-Phe-BNA, glycyl-N-2-naphthalenyl-L-phenylalaninamide
Supplier: Cayman Chemical
Supplier-Nr: 14634-50

Properties

Application: Cathepsin C substrate
Conjugate: No
MW: 347.4 D
Formula: C21H21N3O2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 21438-66-4| Find alternatives
KEGG ID : K01275 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H351
P Phrases: P201, P202, P280, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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