Other Peptides

Heparin-binding peptide is a synthetic peptide fragment corresponding to residues 1,892-1,899 of the C-terminal heparin-binding domain of fibronectin. It induces focal adhesion formation in pre-spread human embryonic fibroblasts (HEFs) when used at concentrations ranging from 1 to 1,000 µg/ml. Heparin-binding...

Kassinin is a tachykinin neuropeptide and agonist of the neurokinin-2 (NK2) and NK3 receptors. It is selective for the NK2 and NK3 receptors over the NK1 receptor. Kassinin (1 µM) increases the short-circuit current in isolated frog skin. It induces contractions in isolated guinea pig ileum and isolated rabbit...

Buccalin A is a neuropeptide that is found in gastropod motor neurons and is involved in neuromuscular signaling. It reduces current-induced muscle contraction amplitude but not muscle relaxation rate in isolated and washed A. californica accessory radula closer (ARC) muscle fibers when used at a concentration of 10...

PF-05190457 is an inverse agonist of the growth hormone secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It selectively binds to GHS-R (Ki = 4.37 nM) over M2 muscarinic acetylcholine receptors (mAChRs, Ki = 1,950 nM) and the serotonin (5-HT) receptor subtype 5-HT2B (IC50 = 3,700 nM)....

Myomodulin A is a gastropod neuropeptide. It is found in gastropod ventral lobe neurons, neural elements of the accessory radula closer (ARC) muscle, and penis nerve. Myomodulin A is biosynthesized by ARC motor neurons in A. californica and potentiates motor neuron-elicited contractions of the A. californica buccal...

Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R, EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor). It decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = 98%. Formulation: (Request formulation change), A solid. Solubility:...

Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R, EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor). It decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = 98%. Formulation: (Request formulation change), A solid. Solubility: Methanol:...

Exendin-4 (3-39) amide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and an active metabolite of exendin-4 (48-86) amide (Cay-11096). It is formed from exendin-4 (48-86) amide in rat liver homogenates. Exendin-4 (3-39) amide induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 9...

Fz7-21 is a peptide antagonist of the frizzled family G protein-coupled receptor 7 (FZD7, IC50 = 100 nM). It inhibits Wnt3a-induced beta-catenin signaling in a reporter assay using HEK293 cells. Fz7-21 (100 µM) reduces the number of cells positive for leucine-rich alpha-2-glycoprotein 5 (Lrg5), a marker of...

F9170 is an antiviral peptide corresponding to amino acids 789-803 of the HIV-1 envelope glycoprotein. It binds to the LLP1 domain within the HIV-1 envelope protein cytoplasmic tail and inhibits HIV-1 IIIB infection of MT-2 cells (EC50 = 0.19 µM). F9170 (3 mg/kg) reduces plasma viral load in a rhesus macaque model...

Wasabi receptor toxin (WaTx) (36-68) is a cell-penetrating peptide that corresponds to the mature toxin sequence and is an activator of transient receptor potential ankyrin 1 (TRPA1). It selectively induces currents in HEK293T cells expressing human TRPA1 (EC50 = 15 nM) over cells expressing human TRP melastatin 8...

Tat-ASIC1a (1-20) is a synthetic peptide composed of the cell-penetrating peptide sequence from the HIV-1 Tat protein transduction domain linked to a 20-amino acid peptide corresponding to amino acids 1-20 of acid-sensing ion channel 1a (ASIC1a). It prevents acid-induced association of ASIC1a with...