Other Peptides

Fexapotide (trifluoroacetate) is a peptide. It induces apoptosis in LNCaP prostate cancer cells when used at a concentration of 2.5 mg/ml. Intraprostatic administration of fexapotide triflutate (0.6 mg/animal per week) reduces the numbers of prostate glandular epithelial cells without affecting other cell types and...

Glucagon-like peptide 1 (GLP-1) (1-32) is an endogenous incretin hormone. It increases intracellular cAMP levels using HEK293 cells expressing human GLP-1 receptor (GLP-1R, EC50 = 0.051 nM). In vivo, GLP-1 (1-32) (30 mg/kg) reduces blood glucose levels in an oral glucose tolerance test (OGTT) in fasted mice.Formal...

Semaglutide side chain is a synthetic intermediate. It has been used as an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide (Cay-40231, Cay-29969, Cay-40170), as well as a lipid side chain to increase the proteolysis-resistance of insulin derivatives for use in...

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid...

MDM2 (32-46) is a peptide fragment of MDM2. Formal Name: ((S)-2-formylpyrrolidin-1-yl)-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-lysyl-L-seryl-L-valylglycyl-L-alanyl-L-glutaminyl-L-lysyl-L-aspartic acid, trifluoroacetate salt. Molecular Formula: C75H135N19O20  XCF3COOH. Formula Weight: 1623.0. Purity:...

HBP08 is a peptide inhibitor of the protein-protein interaction between chemokine (C-X-C motif) ligand 12 (CXCL12) and high mobility group protein B1 (HMGB1). It binds to HMGB1 (Kd = 0.8 µM) and inhibits HMGB1-induced inhibition of CXCL12-induced migration of 300-19 pre-B cells expressing human chemokine (C-X-C...

[Gly8,36,Glu22]-Glucagon-like peptide 1 ([Gly8,36,Glu22]-GLP-1) (7-37) is a derivative of GLP-1 containing alanine-to-glycine, glycine-to-glutamate, and arginine-to-glycine substitutions at positions 8, 22, and 36, respectively, and a peptide fragment of the GLP-1 receptor (GLP-1R) agonist dulaglutide.Formal Name:...

Myristoyl hexapeptide-16 is a myristoylated form of the hexapeptide Leu-Lys-Lys-Ala-Leu-Lys. An acid form of myristoyl hexapeptide-16 is active against E. coli, P. aeruginosa, S. aureus, and methicillin-resistant S. aureus (MRSA, MICs = =100 ppm for all).Formal Name:...

Enramycin A is a lipopeptide antibiotic that has been found in S. fungicidicus. It also inhibits avian myeloblastosis virus reverse transcriptase by 50% when used at a concentration of 10 µg/ml in a cell-free assay. Formulations containing enramycin A have been used as feed additives to prevent bacterial necrotic...

Mechercharmycin A is a cyclic peptide originally isolated from Thermoactinomyces that has anticancer activity. It induces cytotoxicity in A549 lung cancer and Jurkat leukemia cells (IC50s = 40 and 46 nM, respectively).Formal Name:...

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite. PYY, along with neuropeptide Y (NPY, Cay-15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate...

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in...