Blocking Peptides

Peptide corresponding to amino acids 11 to 30 of human origin (1). , Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing...

Peptide (AQFGRGRGWQPFHK) corresponding to amino acids 473 to 486 of murine RIP3 (3). Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype...

, The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identi?ed and designated Smac/DIABLO (1,2). Smac/DIABLO is a...

The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identi?ed and designated Smac/DIABLO (1,2). Smac/DIABLO is a...

Peptide corresponding to amino acids 2 to 16 of human SODD (1). , Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell...

Peptide is used to block SRC-1 Rabbit mAb reactivity in immunohistochemistry protocols. There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA1), SRC-2 (TIF2/GRIP1/NCoA-2) and SRC-3 (ACTR/pCIP/ RAC3/TRAM-1/AIB1). The SRC family members all share significant structural...

Peptide corresponding to amino acids 712 to 750 of human STAT1a (4). The sequences differ from the murine corresponding sequences by four amino acids. , STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression...

Synthetic peptide (AKTTRQSIEQLAA) corresponding to amino acids 128 to 140 of mouse origin., Corresponding antibody recognizes an approximate 17kD band of mouse Survivin. Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members...

Peptide corresponding to amino acids 1 to 12 of human origin (1)., Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP...

Peptide corresponding to amino acids 129 to 142 of human origin, Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a...

Peptide corresponding to amino acids 807 to 823 of human TACE (1,2). This sequence differs from those of mouse and rat TACE by one amino acid (3)., Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a...

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated...